For decades, weight gain and obesity have been viewed through the narrow lens of calorie imbalance—consuming more energy than the body uses. However, recent advancements in metabolic science have reshaped this narrative. Weight gain is not merely a math problem—it is a biological communication issue.

The human body stores fat not just as a fuel reserve, but as an active endocrine organ. Fat cells (adipocytes) release various hormones, including leptin, that play crucial roles in appetite regulation, energy balance, and inflammation.

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